Blacktown Hospital is located in a rapidly developing area of north western metropolitan Sydney.

With excellent road access via three new motorways (the M2, M7 and M4), the city's CBD and Sydney airport are accessible within 30-40 minutes. Blacktown is now serviced by two recently opened Transit ways from rapid growth centres in the northwest and is situated at the intersection of two rail lines - one of which is the main western link for express services.